[ASC-media] Blocking the body’s leaky pipes

Niall Byrne niall at scienceinpublic.com.au
Wed Nov 6 15:19:27 PST 2013

Dear ASC,

Blocking the body’s leaky pipes: Centenary’s discoveries lead to a commercial agreement to create drugs to fix leaking blood vessels

Australian molecular biologists led by researchers at Centenary have made a synthetic compound that appears to allow them to control the leakiness of blood vessels. The work could lead to effective new drug treatments for strokes and tumours. Spinoffs may include an ability to reduce the side-effects of chemotherapy and inflammation.

Their lead drug candidate, known as CD5-2, was developed with the assistance of Mirrx Therapeutics, a privately owned Danish biotechnology company. Today Centenary has signed an agreement to develop this and other potential drugs with Mirrx. The agreement was facilitated by Bio-Link Australia Pty Ltd.

“Control of blood vessel permeability is extremely important for our health,” says Professor Jennifer Gamble of Centenary’s Vascular Biology research group, who heads the research team.  “Within five years, we are hoping to develop drugs which can specifically inhibit the leakiness of blood vessels, a feature that contributes to the pathology of many diseases.”

“Leaky blood vessels, as manifest by tissue swelling that can ultimately obstruct blood supply, is a very important clinical problem from the emergency room all the way to rehabilitation. The potential of a useful drug preventing vascular leak is very exciting and we look forward to its clinical development in collaboration with Mirrx,” says Professor Mathew Vadas, Executive Director of the Centenary Institute.

More information on the research and this new agreement at: http://www.centenarynews.org.au/blocking-the-bodys-leaky-pipes

This research is part of an important body of work underway at Centenary and around the world. The decreased ability of controlling vessel leakiness is one of the signs of blood vessels beginning to wear out or age.

In March 2014, the Centenary Institute is hosting a multidisciplinary conference on the role of inflammation in disease and ageing.  The Future of Experimental Medicine Conference – Inflammation in Disease and Ageing is being organised by Professor Gamble and her colleague Professor Wolfgang Weninger. Find out more about the conference at: http://femc.mtci.com.au/

For interviews or more details, contact: Toni Stevens in my office on 0401 763 130, toni at scienceinpublic.com.au

Kind regards,


Niall Byrne
Creative Director
Science in Public
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