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<title>Re: [ASC-media] Using diet to cope with the aftermath of stroke</title>
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<p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D">Connie’s not making a case for ‘leaky gut syndrome’ which it seems to me is up there with various other alternative ‘syndromes’ where someone argues that x
 is responsible for ‘everything’. I like the description from Wikipedia which I’ve copied below.
<o:p></o:p></span></p>
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<p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D">Connie’s work is really quite neat.<o:p></o:p></span></p>
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<p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D">Over 60 per cent of stroke survivors go on to get infections. And many of them die from them.
<o:p></o:p></span></p>
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<p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D">Connie’s drawn some clever connections and done the science to prove them. When the brain is injured by stroke, white blood cells rally to the call to repair
 the damage. But the brain can’t afford the inflammation that the white blood cells will cause. It’s the body’s natural response to the injury that can cause much of the stroke damage. So the brain suppresses the immune system. And that, she thinks, allows
 normal gut flora in and triggers often deadly infections. The clinicians know about the infection risk and give stroke patients lots of antibiotics. Connie thinks there might be better ways including high fibre diet.
<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D"><o:p> </o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D">I’m guessing that in the fullness of time that as with other ‘grab-bag’ syndromes, we’ll find that there’s a grain of truth to leaky gut syndrome but that much
 of the hype will be overstated. <o:p></o:p></span></p>
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<p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D">And from Prof Wiki…<o:p></o:p></span></p>
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<b><span style="font-size:9.5pt;font-family:"Arial","sans-serif";color:black">Leaky gut</span></b><span class="apple-converted-space"><span style="font-size:9.5pt;font-family:"Arial","sans-serif";color:black"> </span></span><span style="font-size:9.5pt;font-family:"Arial","sans-serif";color:black">(or<span class="apple-converted-space"> </span><b>intestinal
 permeability</b>) is the phenomenon of the<span class="apple-converted-space"> </span><a href="http://en.wikipedia.org/wiki/Human_gastrointestinal_tract" title="Human gastrointestinal tract"><span style="color:#0B0080">gut wall</span></a><span class="apple-converted-space"> </span>exhibiting
 increased<span class="apple-converted-space"> </span><a href="http://en.wikipedia.org/wiki/Semipermeable_membrane" title="Semipermeable membrane"><span style="color:#0B0080">permeability</span></a>.<sup id="cite_ref-ttt_1-0"><a href="http://en.wikipedia.org/wiki/Leaky_gut#cite_note-ttt-1"><span style="color:#0B0080">[1]</span></a></sup><o:p></o:p></span></p>
<p style="mso-margin-top-alt:4.8pt;margin-right:0cm;margin-bottom:6.0pt;margin-left:0cm;line-height:14.4pt;background:white;orphans: auto;text-align:start;widows: auto;-webkit-text-stroke-width: 0px;word-spacing:0px">
<span style="font-size:9.5pt;font-family:"Arial","sans-serif";color:black">In mainstream medicine people with certain gut-related conditions may need treatment to reduce the inflammation of their bowel lining. In<span class="apple-converted-space"> </span><a href="http://en.wikipedia.org/wiki/Alternative_medicine" title="Alternative medicine"><span style="color:#0B0080">alternative
 medicine</span></a><span class="apple-converted-space"> </span>a proposed medical condition, called<span class="apple-converted-space"> </span><b>leaky gut syndrome</b>, has been popularized in which it is thought that substances migrate outwards through the<span class="apple-converted-space"> </span><a href="http://en.wikipedia.org/wiki/Human_gastrointestinal_tract" title="Human gastrointestinal tract"><span style="color:#0B0080">gut
 wall</span></a><span class="apple-converted-space"> </span>with adverse health consequences.<sup id="cite_ref-ttt_1-1"><a href="http://en.wikipedia.org/wiki/Leaky_gut#cite_note-ttt-1"><span style="color:#0B0080">[1]</span></a></sup><o:p></o:p></span></p>
<p style="mso-margin-top-alt:4.8pt;margin-right:0cm;margin-bottom:6.0pt;margin-left:0cm;line-height:14.4pt;background:white;orphans: auto;text-align:start;widows: auto;-webkit-text-stroke-width: 0px;word-spacing:0px">
<span style="font-size:9.5pt;font-family:"Arial","sans-serif";color:black">Proponents of leaky gut syndrome say that an altered or damaged bowel lining or<span class="apple-converted-space"> </span><a href="http://en.wikipedia.org/wiki/Human_gastrointestinal_tract" title="Human gastrointestinal tract"><span style="color:#0B0080">gut
 wall</span></a><span class="apple-converted-space"> </span>results from poor diet,<span class="apple-converted-space"> </span><a href="http://en.wikipedia.org/wiki/Parasite" title="Parasite"><span style="color:#0B0080">parasites</span></a>, infection, or<span class="apple-converted-space"> </span><a href="http://en.wikipedia.org/wiki/Medication" title="Medication"><span style="color:#0B0080">medications</span></a>,
 and that this allows substances such as<span class="apple-converted-space"> </span><a href="http://en.wikipedia.org/wiki/Toxin#Non-technical_usage" title="Toxin"><span style="color:#0B0080">toxins</span></a>, microbes, undigested food or waste to leak through.
 They say this prompts the body to initiate an<span class="apple-converted-space"> </span><a href="http://en.wikipedia.org/wiki/Immune_system" title="Immune system"><span style="color:#0B0080">immune</span></a><span class="apple-converted-space"> </span>reaction
 leading to potentially severe health conditions.<sup id="cite_ref-2"><a href="http://en.wikipedia.org/wiki/Leaky_gut#cite_note-2"><span style="color:#0B0080">[2]</span></a></sup>This theory is vague and largely unproven, and there is no<span class="apple-converted-space"> </span><a href="http://en.wikipedia.org/wiki/Evidence-based_medicine" title="Evidence-based medicine"><span style="color:#0B0080">evidence</span></a><span class="apple-converted-space"> </span>that
 the remedies marketed for treating leaky gut bring the benefits they claim.<sup id="cite_ref-nhs_3-0"><a href="http://en.wikipedia.org/wiki/Leaky_gut#cite_note-nhs-3"><span style="color:#0B0080">[3]</span></a></sup><span class="apple-converted-space"> </span>The
 scientific community continues to debate whether there is a connection between a leaky gut and autism.<sup id="cite_ref-debate_4-0"><a href="http://en.wikipedia.org/wiki/Leaky_gut#cite_note-debate-4"><span style="color:#0B0080">[4]</span></a></sup><o:p></o:p></span></p>
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<span style="font-size:9.5pt;font-family:"Arial","sans-serif";color:black">Some scientists and skeptics have expressed concern that the promotion of leaky gut syndrome is a dishonest ploy designed to make money from the sale of supposed remedies for it.<sup id="cite_ref-nhs_3-1"><a href="http://en.wikipedia.org/wiki/Leaky_gut#cite_note-nhs-3"><span style="color:#0B0080">[3]</span></a></sup><o:p></o:p></span></p>
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<p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Cambria","serif";color:#1F497D">________<o:p></o:p></span></p>
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<p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Cambria","serif";color:#1F497D">Niall Byrne<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Cambria","serif";color:#1F497D"> <o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Cambria","serif";color:#1F497D">Science in Public    <o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Cambria","serif";color:#1F497D">0417 131 977,
<a href="mailto:niall@scienceinpublic.com.au"><span style="color:#1F497D;text-decoration:none">niall@scienceinpublic.com.au</span></a><o:p></o:p></span></p>
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<p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Cambria","serif";color:#1F497D">Full contact details at <a href="http://www.scienceinpublic.com.au/"><span style="color:#1F497D;text-decoration:none">www.scienceinpublic.com.au</span></a><o:p></o:p></span></p>
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<p class="MsoNormal"><b><span lang="EN-US" style="font-size:10.0pt;font-family:"Tahoma","sans-serif"">From:</span></b><span lang="EN-US" style="font-size:10.0pt;font-family:"Tahoma","sans-serif""> Susan Kirk [mailto:skirk@iprimus.com.au]
<br>
<b>Sent:</b> Wednesday, 13 November 2013 9:23 AM<br>
<b>To:</b> Niall Byrne; asc-media@lists.asc.asn.au<br>
<b>Subject:</b> Re: [ASC-media] Using diet to cope with the aftermath of stroke<o:p></o:p></span></p>
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<p class="MsoNormal"><o:p> </o:p></p>
<p class="MsoNormal" style="margin-bottom:12.0pt"><span style="font-size:11.0pt;font-family:"Calibri","sans-serif"">Interesting..the leaky gut syndrome?  Another area that is boohooed.<br>
<br>
S<br>
<br>
<br>
On 12/11/13 5:56 PM, "Niall Byrne" <<a href="niall@scienceinpublic.com.au">niall@scienceinpublic.com.au</a>> wrote:</span><o:p></o:p></p>
<p class="MsoNormal" style="margin-bottom:12.0pt"><b><span style="font-size:11.0pt;font-family:"Gill Sans MT"">$25,000 Centenary Institute Lawrence Creative Prize goes to young Melbourne researcher<br>
</span></b><span style="font-size:11.0pt;font-family:"Cambria","serif"">Dear ASCers,<br>
</span><span style="font-size:11.0pt;font-family:"Calibri","sans-serif""><br>
</span><span style="font-size:11.0pt;font-family:"Cambria","serif"">Tonight, one of Australia’s most creative young medical researchers won a $25,000 prize to help her develop her ideas on how diet could prevent stroke deaths.
<br>
</span><span style="font-size:11.0pt;font-family:"Calibri","sans-serif""><br>
</span><span style="font-size:11.0pt;font-family:"Cambria","serif""><img border="0" width="166" height="222" id="_x0000_i1025" src="cid:image001.jpg@01CEE05A.AE02CA60">Connie Wong thinks we may be able to prevent early deaths following stroke with a fibre-based
 diet. She initially used innovative microscope techniques to determine how stroke weakens the immune system. Now she is studying how it also induces leakiness in the gut wall, leading to infection and an upsurge in deaths. And the solution may well lie in
 diet.<br>
</span><span style="font-size:11.0pt;font-family:"Calibri","sans-serif""><br>
</span><span style="font-size:11.0pt;font-family:"Cambria","serif"">For her proposed ambitious and innovative research program, Dr Wong of the Department of Immunology at Monash University received this year’s $25,000 Centenary Institute Lawrence Creative Prize
 at a ceremony hosted by UBS in Sydney.<br>
</span><span style="font-size:11.0pt;font-family:"Calibri","sans-serif""><br>
</span><span style="font-size:11.0pt;font-family:"Cambria","serif"">Stroke is the second leading cause of mortality in Australia, resulting in more than 10% of all deaths. Of the survivors, over 60% die within a year or become dependent on others. The cost
 to the community annually is more than $2 billion. “So any increase in understanding the mechanisms and consequences of stroke that results in more efficient treatment could have enormous social and economic benefits,” says Dr Wong.<br>
</span><span style="font-size:11.0pt;font-family:"Calibri","sans-serif""><br>
</span><span style="font-size:11.0pt;font-family:"Cambria","serif"">In a post-doctoral fellowship at the University of Calgary in Canada, Connie showed that stroke triggers a release of compounds by the nervous system, seemingly to reduce the level of inflammation
 in the brain. But this is at the cost of weakening the response of the immune system to infection generally.
<br>
</span><span style="font-size:11.0pt;font-family:"Calibri","sans-serif""><br>
</span><span style="font-size:11.0pt;font-family:"Cambria","serif"">In particular, Connie found that these compounds change the behaviour of the white blood cells known as invariant natural killer T cells. As a result the body becomes increasingly susceptible
 to infection after a stroke, and that correlates with a subsequent upsurge in deaths from infectious diseases.<br>
</span><span style="font-size:11.0pt;font-family:"Calibri","sans-serif""><br>
</span><span style="font-size:11.0pt;font-family:"Cambria","serif"">Now Connie wants to investigate a linked observation that the gut wall becomes more permeable immediately following a stroke, allowing normally harmless gut bacteria to move into the body where
 they can initiate infection. She suspects that the combination of the leakiness of the gut and the reduced ability of the immune system to guard against bacteria, and that may be the cause of increased vulnerability to infection after a stroke. She now wants
 to explore if this can be alleviated by an appropriate, fibre-based diet.<br>
</span><span style="font-size:11.0pt;font-family:"Calibri","sans-serif""><br>
</span><span style="font-size:11.0pt;font-family:"Cambria","serif"">“Exceptional young scientists can be hard to keep in Australia and we hope this award will not only celebrate their achievements but also encourage a domestic culture of brilliance in this
 truly important field,” says Centenary Institute Executive Director, Professor Mathew Vadas AO.<br>
</span><span style="font-size:11.0pt;font-family:"Calibri","sans-serif""><br>
</span><span style="font-size:11.0pt;font-family:"Cambria","serif"">The two other finalists who each received $5,000 to go towards their research, were:<br>
</span><span style="font-size:11.0pt;font-family:"Calibri","sans-serif""><br>
</span><span style="font-size:11.0pt;font-family:Symbol">· </span><span style="font-size:11.0pt">       </span><b><span style="font-size:11.0pt;font-family:"Cambria","serif"">Dr William (Will) Ritchie</span></b><span style="font-size:11.0pt;font-family:"Cambria","serif"">
 from the Centenary Institute, who has used statistics to unmask a molecular mechanism that cells use to regulate the levels of individual proteins. Future development of this work could lead to drug therapies for leukaemia, Alzheimer’s disease, cardiac disease
 and liver cancer. He is now modifying his statistical tool to allow medical laboratories to detect the new mechanism— intron retention—quickly and easily.<br>
</span><span style="font-size:11.0pt;font-family:"Calibri","sans-serif""><br>
</span><span style="font-size:11.0pt;font-family:Symbol">· </span><span style="font-size:11.0pt">       </span><b><span style="font-size:11.0pt;font-family:"Cambria","serif"">Dr Anne Abbott</span></b><span style="font-size:11.0pt;font-family:"Cambria","serif"">
 from Monash University, who is transforming the prevention of carotid artery stroke. She has shown that a healthy lifestyle and medication are now better than surgery or stenting for preventing stroke in patients with symptomless narrowing of the carotid artery.
 But that wasn’t enough. She’s has successfully campaigned to get the international medical establishment to update health policy, guidelines and practice.<br>
</span><span style="font-size:11.0pt;font-family:"Calibri","sans-serif""><br>
</span><span style="font-size:11.0pt;font-family:"Cambria","serif"">The Centenary Institute Lawrence Creative Prize is awarded for creative biomedical research excellence. Since 2011, the prize has had nine finalists and more than 30 semi-finalists.
<br>
</span><span style="font-size:11.0pt;font-family:"Calibri","sans-serif""><br>
</span><span style="font-size:11.0pt;font-family:"Cambria","serif"">“We believe the prize has identified a core of Australia’s creative talent and created an alumni of young medical researchers who are not only aware of current issues but are not afraid to
 attack tomorrow’s problems,” said Professor Vadas.<br>
</span><span style="font-size:11.0pt;font-family:"Calibri","sans-serif""><br>
</span><span style="font-size:11.0pt;font-family:Symbol">· </span><span style="font-size:11.0pt">       </span><span style="font-size:11.0pt;font-family:"Cambria","serif"">To arrange interviews, contact Tamzin Byrne,
<a href="tamzin@scienceinpublic.com.au">tamzin@scienceinpublic.com.au</a>, 0432 974 400<br>
</span><span style="font-size:11.0pt;font-family:"Calibri","sans-serif""><br>
</span><span style="font-size:11.0pt;font-family:Symbol">· </span><span style="font-size:11.0pt">       </span><span style="font-size:11.0pt;font-family:"Cambria","serif"">High res photos and more information on the prize at
<a href="http://www.scienceinpublic.com.au/centenary">www.scienceinpublic.com.au/centenary</a> <<a href="http://www.centenary.org.au/p/about/lawrencecreative/">http://www.centenary.org.au/p/about/lawrencecreative/</a>>  <br>
</span><span style="font-size:11.0pt;font-family:"Calibri","sans-serif""><br>
</span><span style="font-size:11.0pt;font-family:"Cambria","serif""><br>
</span><span style="font-size:11.0pt;font-family:"Calibri","sans-serif""><br>
</span><span style="font-size:11.0pt;font-family:"Cambria","serif"">Kind regards,<br>
</span><span style="font-size:11.0pt;font-family:"Calibri","sans-serif""><br>
</span><span style="font-size:11.0pt;font-family:"Cambria","serif"">Niall<br>
</span><span style="font-size:11.0pt;font-family:"Calibri","sans-serif""><br>
________<br>
</span><span style="font-size:11.0pt;font-family:"Cambria","serif"">Niall Byrne<br>
</span><span style="font-size:11.0pt;font-family:"Calibri","sans-serif""><br>
Creative Director<br>
Science in Public<o:p></o:p></span></p>
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